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Hundreds of years ago, Lady Alustriel of Silverymoon needed a secure place to conduct sensitive magic work and research. After discovering a portal from Silverymoon to Sigil, Alustriel traveled to Sigil. There she spent decades creating a private sanctum around the portal.
Alustriel magically fused the portal in her sanctum with a Well of Many Worlds, destroying the magic item in the process. As a result, the portal now leads to numerous locations throughout the multiverse. Further, the portal reacts to magic items and artifacts, allowing those who carry such objects to step through the portal to the exact places they wish to travel. Alustriel carefully maintains the sanctum’s secrecy, bringing guests here only after first meeting them in a neutral location. So far, either her portal’s strange teleportation properties have gone unnoticed by Sigil’s Lady of Pain and her agents, or the Lady of Pain is allowing the portal to function this way for reasons of her own.